Seabridge Bioenergetics

More evidence that polyunsaturated fatty acids, are directly causative in insulin resistance.

“In skeletal muscle, FFAs inhibit insulin-stimulated glucose uptake at the level of glucose transport and/or phosphorylation (4,5) through mechanisms that involve intramyocellular accumulation of diacylglycerol (DAG) and long-chain acyl-CoA, activation of protein kinase C (PKC), and decreased tyrosine phosphorylation of insulin receptor substrate 1/2 (IRS-1/2) (6,7).”

…” In summary, we found that physiological elevations of plasma FFAs for 4 h caused hepatic insulin resistance (i.e., increased hepatic glucose production), resulted in hepatic accumulation of DAG, activation of two serine/threonine kinases (PKC-δ and IKK-β), activation of the classic proinflammatory IKK/IκB/NF-κB pathway, increased hepatic expression (IL-1β and TNF-α), and increased plasma levels (MCP-1) of inflammatory cytokines. These results suggested that obesity-associated hepatic insulin resistance and obesity-associated subacute hepatic inflammation could be the result of elevated plasma FFA levels.”

https://diabetesjournals.org/diabetes/article/54/12/3458/14006/Free-Fatty-Acids-Produce-Insulin-Resistance-and

Now I did some research on what kinds of fatty acids were used to cause insulin resistance, and what i found was interesting. They basically injected the rats with seed oils very high in omega-6 PUFA’s at it caused insulin resistance in them.