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Continue reading →: Kendte HIV Protease inhibitorer er TLR (Toll like receptor) inhiberende. Endotoksin driver i AIDS pathogenesen?
Interessante fund, der kan være en brik i puslespillet til at forstå AIDS pathogenesen. HIV protease inhibitoren Saquanavir inhiberer HMGB-1 drevet inflammation, ved at ramme interaktionen mellem Cathepsin V ig TLR4/MyD88https://pubmed.ncbi.nlm.nih.gov/26349060/ Et andet studie finder lignende immunmodulerende effekter af proteasehæmmere. “These data suggest that PI block HIV replication not only…
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