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Continue reading →: Dietary PUFA -driver of the mammalian hibernation state and Human Obesity?TL;DR: PUFA induces af stress response in the liver that turns on the aryl hydrocarbon receptor AHR.This turns up transctiption of the fat storage programming, which down the line acts to increase transcription of SCD1 and other fat storage/lipogenic enzymes – SCD1 turns Saturated fats to monounsatured fats, and now…
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Continue reading →: (Mild) Uncoupling of oxidative phosphorylation. Increases lifespan, decreases inflammation, upregulates OXPHOS enzymes and metabolic rateUncoupling is like pressing the speeder down in your car without putting it into gear. The motor runs on high revolutions creating heat and burning fuel, but is not coupled to the forward propulsion of the wheels. The energy is lost as heat instead of rotating the wheels. Biology is…
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Continue reading →: Methionine restriction – improved mitochondrial function, fat loss and insulin sensitivity- might increase lifespan by downregulation of mTOR pathway.Maybe the high sugar vegans are not so crazy after all – and the carnivore crowd might have something to think about. Might the so called benefits of calorie restriction even be confounded with all the benefits of methionine restriction? Methionine, an essential amino acid is the main source of…
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Continue reading →: Over baseline Fatty acid oxidation impairs glucose metabolism, creates reductive stress, free radical damage and inflammation. Glucose combustion less damaging and inflammatory.
We shall now look at how fatty acid combustion causes an impairment in the electron flow and an overweight towards reduction in the redox balance of electron carriers, and how it generates a higher amount of reactive oxygen species when a there is an overweight towards the reductive state in…
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Continue reading →: Co2 protects oxidative phosphorylation by protecting cytochrome c oxidase in the electron transport chain from nitric oxide inhibitionIn this article we shall look at how high levels of Co2 from glucose metabolism acts as the main vasodilator preventing the over baseline use of nitric oxide as an emergency vasodilator, how nitric oxide inhibits respiration on cytochrome c oxidase in the electron transport chain and how co2 competes…
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Continue reading →: Carbon monoxide, the new doping in cycling?This article will cover arguments, that carbonmonoxide inhalations might cause increased erythropoiesis, mitochondrial efficiency and mitochondrial density – speculatively also might be a performance enhancer explaining recent quantum jumps in perfomances in pro cycling. Recently we have heard speculations on social media, that in pro cycling, carbon monoxide is the…
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Continue reading →: ADHD noget så simpelt som sukker mangel i hjernen og især præfrontale cortex?
Min arbejdshypotese omkring ADHD har længe været at det er en slags energi mangel i hjernen. Den hypotese får nu lidt tungere vægt, da det ser ud til at ADHD’s/ opmærksomhedsforstyrrelsens årsag skal findes i en nedsat glukose metabolisme i hjernen både regionalt og globalt. 8,1 % lavere cerebral glukose…
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Continue reading →: Jonas Vingegaard har verdens bedste mitokondrielle energi effektivitet – og hvorfor han vinder Tour de France 2024Kongen af Touren er tilbage, nærmest som Herkules der vender tilbage fra underverdenens dyb, hvor han tabte sin sidste Guddom, og næsten tabte livet. Men han er tilbage for at kæmpe på lige vilkår med andre dødelige. Han er tilbage for at skulle bevise endeligt, sit sande heltemod.Hvis Jonas Vingegaard…
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Continue reading →: Endotoxæmi og en stigning af markører for tarmpermeabilitet efter indtag af sukker sødet vand, men ikke af frugt juice.
Et helt nyt studie udgivet i Nature, ses det, at der efter indtag af henholdsvis en halv liter sukker sødet vand, almindelig usødet vand og til sidst frugt juice, er vidt forskellige mikrobielle reaktioner i tarmen. Endotoxin receptoren TLR2, der registrer bakterielle komponenter fra især gram positive bakterier, er signifikant…
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Continue reading →: Fedtsyre (PUFA) induceret inflammation driver i diabetes type 2?
Lidt baggrund for type 2 diabetes. Type 2 diabetes defineres i korte træk som en blanding af insulinresistens og beta celle dysfunktion, hvorved insulinproduktionen ikke er tilstrækkelig. Inden man når til stadiet der hedder type 2 diabetes, kan man have insulinresistens i årevis op til at pancreas funktionen forringes i…
Welcome to my blog about cellular physiology and bioenergetics.
This is where I show you what I find in my search for trying to understand how cellular energy relates to modern disease.
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- ADHD -neuroinflammation og neurotransmitterforstyrrelser som følge af lave vitamin D niveauer?
- ADHD – B6 vitamin mangel – ophør af symptomer ved behandling med B6
- Du har ikke ADHD, du er forgiftet – PUFA på banen igen
- Why are PUFA’s so bad?
- Vitamin D. Anticancer, performance enhancing, anti inflammation, antidepressive, antiviral, anti-aromatase, anti pufa.
Seabridge Bioenergetics 